Exercise in Pill Form May Answer Prayers of Many
Most of us would have a hard time trying to discern the links between world-class athletes, veterans suffering from physical disabilities, couch potatoes, and the frail, the elderly, and the obese but researchers at the Salk Institute for Biological Studies would tell us they’re all likely candidates for a new drug they’ve been investigating that mimics the healthful effects of exercise. Tested only on laboratory mice, the mice getting the drug dramatically increased endurance during exercise, did not gain weight on a high-fat diet, and their body’s response to insulin improved as well.
This exercise-in-a-pill is not available commercially but the potential it poses for athletes participating in endurance-type sports, such as long-distance running, is so strong that the research team is working with the World Anti-Doping Association to develop a test that detects the drug in the blood and urine. They hope to have the test ready before the Summer Olympics games begin next week.
Adenosine Triphosphate (ATP) is the main form of energy stored in the muscle. During times of high physical demand ATP gets converted to a new chemical, Adenosine Monophosphate (AMP). AMP alerts AMPK, which works like a master regulator for the metabolism. AMP signals a genetic switch, PPAR delta, to increase endurance levels.
A drug used for investigational purposes only, GW1516, acts like a direct switch to the PPAR delta, causing it to switch to endurance performance even when no exercise or physical exertion is in progress. The Salk research team wanted to know if the exercise-induced health benefits would be produced by the GW1516 alone.
When lab mice were treated with GW1516 for four weeks, invisible benefits were documented. Blood glucose and fatty acids levels dropped but there was no visible evidence of improved physical performance although the mice were not required to exercise at this stage of the study.
Switching tactics, however, the research team subjected the mice to 50 minutes a day on a treadmill plus the GW1516. The dramatic result of the exercise/drug combo increased endurance by as much as 77% over mice who underwent the same exercise program without the added drug. A specific type of muscle tissue, called “slow twitch” and “non-fatiguing,” increased, too, by about 38%.
Further research revealed that the exercise/drug combo worked best because the exercise causes the cytoplasm, which surrounds the nucleus of the cell, to release AMPK molecules, some of which enter the nucleus, where the PPAR delta is found. Once activated by the AMPK molecules, the PPAR delta becomes turbo-charged in the presence of GW1516, which explains how the mice were able to exercise 44% longer than mice not treated with the drug and not trained for exercising.
The story of the exercise in a pill is in the July 31 online advance edition of the medical journal, Cell. The Howard Hughes Medical Institute, the National Institute of Health, and the Hillblom Foundation all provided support for the study.
Source: Salk Institute for Biological Studies
Since the Dr. Sinclair study on resveratrol’s ability to switch on the anti-aging gene Sirt-1 was published in Nature a flood of somewhat dubious companies have sprung up selling resveratrol. Most of the dodgy ones have some variation of resveratrol in their name and sell only one or two products. One even makes his capsules in a rented house in Florida. Consumer Lab, an independent testing authority, evaluated the major brands and found many lacking in content and quality. The high potency ones that passed their evaluation were Transmax and Bioforte by http://www.biotivia. A product by Life Extension Co. failed badly with only 26% of the claimed resveratrol. Another brand, Revatrol, had virtually no trans-resveratrol in its supplement. The problem with some of the ones that did pass is that they contain less than 250mg of actual resveratrol which does not conform to the studies and is very expensive on a relative mg basis. The ConsumerLab test results are available on their web site.
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Thanks for such an important articles about Anti Aging. This is a very needed because my friend sis is suffering from anti aging and i want to help her.
so please guide me.
great post!
resveratrol supplement does not offset excercise tho. it is better to do both!
Yeah, I would highly recommend a mix of exercise and resveratrol supplementation in order to achieve the best possible result!
Start with one of those free trials to find out if Resveratrol is right for you!
The thing I have noticed about the different anti-cancer berries that we keep on hearing about (red wine grapes, acai, blueberry, mangosteen, ) all have properties to antioxidate, or clean the blood and organ tissue cells of toxins and free radicals. Having a body with less toxins does promote a longer, healthy life.
Acia Berry…
Acai Berry offers so many benefits for good health and weight loss that it would be a pity to spoil the experience by dealing with crooks – is it worth the risk?…
I always make sure that i get an exercise each day, exercise keeps me fit and healthy.–~
i alway love to exercise during the day because it energizes me`~’
i always exercise at leat 3 times a week to develope fuller muscles and cut down on body fat,~:
i always make sure that i take exercise at least 3 times a week’:,
i do a lot of heavy exercise twice a week and it really helped my health to be on excellent condition ‘:’
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